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Hydroxychloroquine with higher dosages or prolonged drug use, gastroin- testinal distress, nausea, headache, pruritus, and hydroxychloroquine plaquenil , like chloroquine, is a leukopenia can occur.

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, mefloquine lariam , sulfadoxine pyrimethamine fansidar , chloroquine aralen are acceptable after a period of observation for adverse effects.

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If chloroquine is recommended for prevention it should be started a week before travel to the malarious region.

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Hydroxychloroquine in lupus pregnancy.

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Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4 .

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