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For people on higher doses of fluoxetine, the dose should be reduced gradually over a number of weeks to reduce the chance of side effects.

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Also, taking amitriptyline, clomipramine, or imipramine with fluoxetine may increase the chance of developing the serotonin syndrome.

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In addition, in vitro studies have shown ketoconazole, a potent inhibitor of cyp3a activity, to be at least 100 times more potent than fluoxetine or norfluoxetine as an inhibitor of the metabolism of several substrates for this enzyme, including astemizole, cisapride, and midazolam.

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